Genetically-stable engineered optogenetic gene switches modulate spatial cell morphogenesis in two- and three-dimensional tissue cultures
Hannes M Beyer, Sant Kumar, Marius Nieke, Carroll M C Diehl, Kun Tang, Sara Shumka, Cha San Koh, Christian Fleck, Jamie A Davies, Mustafa Khammash, Matias D Zurbriggen · 2024
Read Genetically-stable engineered optogenetic gene switches modulate spatial cell morphogenesis in two- and three-dimensional tissue cultures by Hannes M Beyer, Sant Kumar, Marius Nieke, Carroll M C Diehl, Kun Tang, Sara Shumka, Cha San Koh, Christian Fleck, Jamie A Davies, Mustafa Khammash, Matias D Zurbriggen (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11612184.txt.
Description
Hannes Beyer and ten co-authors wire light-controlled gene switches into lab-grown tissues, in a study from twenty twenty-four. Growing tissues in dishes is now routine, but steering cell behavior with precision in place and time stayed hard. Genetic switches that answer to light offer that steering, if they sit stably in the genome at low copy counts.
Blue and red light switches were built into flat and three-dimensional mammalian tissues. With patterned lamps, mirrors, masks, and lasers, the team triggered cell death and a growth signal in chosen spots only. Patterns formed where the light fell, at fine detail. The authors say such programmable tissues could serve research and future therapies.
Catalog record
| CREATOR | Hannes M Beyer, Sant Kumar, Marius Nieke, Carroll M C Diehl, Kun Tang, Sara Shumka, Cha San Koh, Christian Fleck, Jamie A Davies, Mustafa Khammash, Matias D Zurbriggen |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 79 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |