Deciphering the pharmacological mechanism of Radix astragali for allergic rhinitis through network pharmacology and experimental validation
Yiwei Hua, Xi Tan, Jingwen Zhang, Ningcong Xu, Ruien Chen, Shiqing Zhou, Shaoqing Liu, Kai Li, Wenyong Chen, Qiulan Luo, Yunying Li · 2024
Read Deciphering the pharmacological mechanism of Radix astragali for allergic rhinitis through network pharmacology and experimental validation by Yiwei Hua, Xi Tan, Jingwen Zhang, Ningcong Xu, Ruien Chen, Shiqing Zhou, Shaoqing Liu, Kai Li, Wenyong Chen, Qiulan Luo, Yunying Li (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11612164.txt.
Description
Hua and ten colleagues study Radix Astragali, a traditional herb, for allergic rhinitis in twenty twenty-four. The herb is known for potential benefit in this nasal allergy condition. Its pharmacological mechanisms were unclear. The team combined network pharmacology with lab validation.
They found hundreds of potential targets for the herb's key compounds. Intersecting those with disease targets gave a shared target set. Network analysis highlighted central inflammatory nodes, including TNF and NF-kB related proteins. Enrichment pointed to inflammatory and immune signaling pathways. Docking studies showed strong, stable binding to the central targets. In a nasal inflammation model, the herb reversed key inflammatory markers. The authors propose a multitarget anti inflammatory action.
Catalog record
| CREATOR | Yiwei Hua, Xi Tan, Jingwen Zhang, Ningcong Xu, Ruien Chen, Shiqing Zhou, Shaoqing Liu, Kai Li, Wenyong Chen, Qiulan Luo, Yunying Li |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |