WWP1 targeting PTEN for polyubiquitination to promote bone metastasis of luminal breast cancer
Hao Jiang, Zhenxi Li, Wei Xu, Jianru Xiao · 2024
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Description
Hao Jiang, Zhenxi Li, Wei Xu, and Jianru Xiao trace why one breast cancer type homes to bone. Their study, from twenty twenty-four, covers luminal breast cancer, which often returns in bone. A protein called WWP1 runs high in these tumors and marks a worse outlook. The team probes how it acts on PTEN, a brake protein that slows cancer growth.
WWP1 tags PTEN with chains that mark it for removal. With the brake gone, cancer cells gain the push to settle in bone early. Cell and tissue tests support that chain of events. Blocking WWP1 could be a way to cut bone spread. The work gives a clear target for drug design.
Catalog record
| CREATOR | Hao Jiang, Zhenxi Li, Wei Xu, Jianru Xiao |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 29 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |