Discovery of anti-SARS-CoV-2 S2 protein antibody CV804 with broad-spectrum reactivity with various beta coronaviruses and analysis of its pharmacological properties in vitro and in vivo
Yoji Tsugawa, Kentaro Furukawa, Tomoko Ise, Masahiro Takayama, Takeshi Ota, Takayuki Kuroda, Shinya Shano, Takashi Hashimoto, Haruyo Konishi, Takeshi Ishihara, Masaaki Sato, Haruhiko Kamada, Keita Fukao, Takao Shishido, Mai Yoshikawa, Tatsuya Takahashi, Satoshi Nagata · 2024
Read Discovery of anti-SARS-CoV-2 S2 protein antibody CV804 with broad-spectrum reactivity with various beta coronaviruses and analysis of its pharmacological properties in vitro and in vivo by Yoji Tsugawa, Kentaro Furukawa, Tomoko Ise, Masahiro Takayama, Takeshi Ota, Takayuki Kuroda, Shinya Shano, Takashi Hashimoto, Haruyo Konishi, Takeshi Ishihara, Masaaki Sato, Haruhiko Kamada, Keita Fukao, Takao Shishido, Mai Yoshikawa, Tatsuya Takahashi, Satoshi Nagata (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11611099.txt.
Description
Yoji Tsugawa and colleagues published a 2024 study of an antibody against coronaviruses. The antibody targets a stable part of the spike protein. That region changes little across related viruses. Future animal coronaviruses could jump into humans. Broadly acting drugs would help meet that threat.
The new antibody bound many human and animal coronaviruses. It did not neutralize virus directly in lab tests. Instead, it helped immune cells kill infected cells. In animal models, it slowed disease from COVID infection. Structural work mapped exactly where it attaches. Such antibodies could stockpile protection against unknown outbreaks.
Catalog record
| CREATOR | Yoji Tsugawa, Kentaro Furukawa, Tomoko Ise, Masahiro Takayama, Takeshi Ota, Takayuki Kuroda, Shinya Shano, Takashi Hashimoto, Haruyo Konishi, Takeshi Ishihara, Masaaki Sato, Haruhiko Kamada, Keita Fukao, Takao Shishido, Mai Yoshikawa, Tatsuya Takahashi, Satoshi Nagata |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |