Proteomic insights into circadian transcription regulation: novel E-box interactors revealed by proximity labeling
Manon Torres, Marieluise Kirchner, Caroline G. Marks, Philipp Mertins, Achim Kramer · 2024
Read Proteomic insights into circadian transcription regulation: novel E-box interactors revealed by proximity labeling by Manon Torres, Marieluise Kirchner, Caroline G. Marks, Philipp Mertins, Achim Kramer (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11610934.txt.
Description
Manon Torres and co-authors hunt for proteins that bind a key clock site in DNA, in a 2024 study. Body clocks run on a near daily cycle and switch genes on and off in rhythm. The site in view helps a clock protein turn on a gene called Dbp in mouse cells.
The team tagged proteins near the site at the hour the clock protein binds. They found sixty-nine proteins there, among them known clock partners, which shows the method works. Three new finds, when drained from human cells, broke the daily rhythm. The work opens a way to film the full cast of clock control over a day.
Catalog record
| CREATOR | Manon Torres, Marieluise Kirchner, Caroline G. Marks, Philipp Mertins, Achim Kramer |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |