PROSER1 modulates DNA demethylation through dual mechanisms to prevent syndromic developmental malformations
Anna Fleming, Elena V Knatko, Xiang Li, Ansgar Zoch, Zoe Heckhausen, Stephanie Stransky, Alejandro J Brenes, Simone Sidoli, Petra Hajkova, Dónal O'Carroll, Kasper D Rasmussen · 2024
Read PROSER1 modulates DNA demethylation through dual mechanisms to prevent syndromic developmental malformations by Anna Fleming, Elena V Knatko, Xiang Li, Ansgar Zoch, Zoe Heckhausen, Stephanie Stransky, Alejandro J Brenes, Simone Sidoli, Petra Hajkova, Dónal O'Carroll, Kasper D Rasmussen (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11610933.txt.
Description
An eleven-author team uncovers a protein that both helps and hinders the erasing of DNA methylation. Methyl tags on DNA steer development, and the TET enzymes remove them. PROSER1, a partner of those enzymes, was recently tied to a severe developmental disorder. The team shows it binds every TET family member and holds them in stable complexes on the genome, where they open developmental genes.
Surprisingly, the same protein also shelves spare TET enzymes away from the genome. That shelving stops runaway demethylation and keeps jumping genetic elements silent. Losing the balance in either direction distorts development. The authors cast PROSER1 as a dial with two hands. One presses the enzymes into service, and the other holds them back. They link that dual control to the malformations seen when the protein fails.
Catalog record
| CREATOR | Anna Fleming, Elena V Knatko, Xiang Li, Ansgar Zoch, Zoe Heckhausen, Stephanie Stransky, Alejandro J Brenes, Simone Sidoli, Petra Hajkova, Dónal O'Carroll, Kasper D Rasmussen |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |