Notch induces transcription by stimulating release of paused RNA polymerase II
Julia M Rogers, Claudia A Mimoso, Benjamin JE Martin, Alexandre P Martin, Jon C Aster, Karen Adelman, Stephen C Blacklow · 2024
Read Notch induces transcription by stimulating release of paused RNA polymerase II by Julia M Rogers, Claudia A Mimoso, Benjamin JE Martin, Alexandre P Martin, Jon C Aster, Karen Adelman, Stephen C Blacklow (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11610932.txt.
Description
Julia Rogers and co-authors uncover how the Notch signal switches genes on in a 2024 study. Notch is a cell-surface protein that, once cut, sends a fragment to the nucleus to steer cell fate. Which step it controls in gene activation stayed murky despite years of work.
The team tracked chromatin access and fresh RNA output across a time course after turning on human Notch1. Target genes fired mainly because stalled RNA polymerase machines were released to run. That release, not new opening of DNA, did the work. Open chromatin at Notch response sites was already in place before the signal, laid down by a remodeling complex. The picture puts the pre-set state of the genome in charge of the response.
Catalog record
| CREATOR | Julia M Rogers, Claudia A Mimoso, Benjamin JE Martin, Alexandre P Martin, Jon C Aster, Karen Adelman, Stephen C Blacklow |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |