Classifying the molecular functions of transcription factors beyond activation and repression
Jinhong Dong, Michael J Guertin · 2024
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Description
Jinhong Dong and Michael Guertin comment on new work about how the Notch signaling pathway switches genes on in a 2024 article. Notch is an ancient cell-to-cell signal that shapes development and keeps tissues in balance. Its end point is a protein complex that enters the nucleus and changes gene activity, and factors were long sorted simply into activators and repressors.
The study they discuss used a fast Notch activation system with genome-wide profiling. It showed the complex turns on its direct target genes mainly by releasing paused RNA polymerase, the enzyme that reads genes, so it can proceed. A chromatin-opening complex also helps by keeping target genes accessible. Dong and Guertin place these findings in a broader push to classify transcription factors by what they actually do.
Catalog record
| CREATOR | Jinhong Dong, Michael J Guertin |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 7 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |