Xylose utilization promotes Salmonella replication within macrophages and systemic infection in mice
Xinyue Wang, Yuyang Sun, Houliang Guo, Xiaolin Yan, Shuai Ma, Bin Yang, Lingyan Jiang · 2024
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Description
Xinyue Wang and six co-authors show that a common sugar helps Salmonella thrive inside host cells in a 2024 study. Salmonella lives and multiplies inside macrophages, the immune cells meant to kill it, and from there it can spread through the body. Xylose is the second most common sugar in nature, and the germ can grow on it alone, yet its role in infection was unknown.
Infected macrophages held more xylose, and the germ switched on its xylose-eating genes inside them. Mutants that could not use xylose grew poorly in macrophages and spread weakly in mice. A sensing system that fires when glucose runs low turned the pathway on. The authors name xylose a backup fuel for the germ.
Catalog record
| CREATOR | Xinyue Wang, Yuyang Sun, Houliang Guo, Xiaolin Yan, Shuai Ma, Bin Yang, Lingyan Jiang |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |