Cell therapy for a rare disease- hairy cell leukemia variant
Claire Fritz, Derek P Wong, Philip Rock, Richard Burack, Akshaya Radhakrishnan, Reshmi Parameswaran · 2024
Read Cell therapy for a rare disease- hairy cell leukemia variant by Claire Fritz, Derek P Wong, Philip Rock, Richard Burack, Akshaya Radhakrishnan, Reshmi Parameswaran (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11610546.txt.
Description
Claire Fritz and co-authors test a cell therapy for a rare variant of hairy cell leukemia in a 2024 paper. The disease is a slow blood cancer of mature B cells, and many patients resist the standard first line drugs. The team built immune cells carrying a receptor aimed at a family of B cell targets.
Patient cells carried all three target receptors at high levels. In dishes, the engineered cells killed both cell lines and patient tumor cells, and they switched on strongly while doing so. Cells made from a patient's own blood also killed tumor cells, including those from another patient. In two mouse models, treatment shrank tumors and lengthened survival without clear toxicity. The authors propose the therapy for trials in this hard to treat group.
Catalog record
| CREATOR | Claire Fritz, Derek P Wong, Philip Rock, Richard Burack, Akshaya Radhakrishnan, Reshmi Parameswaran |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |