A phase II study of post-remission therapy with pembrolizumab in older patients with acute myeloid leukemia
Kevin Quann, Konstantinos Lontos, Alison Sehgal, Anastasios Raptis, Annie Im, Robert L. Redner, Kathleen A. Dorritie, Mounzer Agha, Jing-Zhou Hou, Rafic Farah, James Rossetti, Daniel P. Normolle, Theresa L. Whiteside, Yen-Michael Sheng Hsu, Michael Boyiadzis · 2024
Read A phase II study of post-remission therapy with pembrolizumab in older patients with acute myeloid leukemia by Kevin Quann, Konstantinos Lontos, Alison Sehgal, Anastasios Raptis, Annie Im, Robert L. Redner, Kathleen A. Dorritie, Mounzer Agha, Jing-Zhou Hou, Rafic Farah, James Rossetti, Daniel P. Normolle, Theresa L. Whiteside, Yen-Michael Sheng Hsu, Michael Boyiadzis (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11609814.txt.
Description
Kevin Quann and a large team of co-authors report a phase two trial of an immune drug for older patients with acute myeloid leukemia, in a 2024 paper. Relapse is the main killer for these patients once the cancer first clears, and many are too frail for a stem cell transplant. A pill already in use stretches remission by a few months, but most patients still relapse, so the team looks for a stronger guard.
The drug, pembrolizumab, frees T cells to attack cancer by blocking a brake called PD-1. The trial gives it every three weeks for up to two years after remission, in patients aged sixty and up. The plan tests whether the drug can hold off relapse, and tracks how it changes immune cell work.
Catalog record
| CREATOR | Kevin Quann, Konstantinos Lontos, Alison Sehgal, Anastasios Raptis, Annie Im, Robert L. Redner, Kathleen A. Dorritie, Mounzer Agha, Jing-Zhou Hou, Rafic Farah, James Rossetti, Daniel P. Normolle, Theresa L. Whiteside, Yen-Michael Sheng Hsu, Michael Boyiadzis |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 18 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |