MYC Drives mRNA Pseudouridylation to Mitigate Proliferation-Induced Cellular Stress during Cancer Development
Jane Ding, Mohit Bansal, Yuxia Cao, Bingwei Ye, Rui Mao, Anamika Gupta, Sunil Sudarshan, Han-Fei Ding · 2024
Read MYC Drives mRNA Pseudouridylation to Mitigate Proliferation-Induced Cellular Stress during Cancer Development by Jane Ding, Mohit Bansal, Yuxia Cao, Bingwei Ye, Rui Mao, Anamika Gupta, Sunil Sudarshan, Han-Fei Ding (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11609627.txt.
Description
Jane Ding and co-authors show how the cancer driver MYC rewires RNA editing to protect fast-growing tumor cells. Pseudouridylation, a common RNA modification, stiffens RNA and shapes how it is processed and read. The team finds that MYC proteins switch on the gene for the enzyme PUS7 during cancer development.
Without PUS7, MYC-driven cancer cells and grafted tumors falter. The enzyme supports stress responses and the making and importing of amino acids, with the regulator ATF4 as a key downstream partner. Stress and MYC both need PUS7 to raise ATF4. The chain offers a fresh target: block the editor, and MYC's growth program may starve.
Catalog record
| CREATOR | Jane Ding, Mohit Bansal, Yuxia Cao, Bingwei Ye, Rui Mao, Anamika Gupta, Sunil Sudarshan, Han-Fei Ding |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 64 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |