Efficacy and Safety of the Anti-IL1RAP Antibody Nadunolimab (CAN04) in Combination with Gemcitabine and Nab-Paclitaxel in Patients with Advanced/Metastatic Pancreatic Cancer
Eric Van Cutsem, Joelle Collignon, Rikke L. Eefsen, Sebastian Ochsenreither, Zanete Zvirbule, Audrius Ivanauskas, Dirk Arnold, Edita Baltruskeviciene, Per Pfeiffer, Jeffrey Yachnin, Susanne Magnusson, Camilla Rydberg Millrud, Annika Sanfridson, Nedjad Losic, Ignacio Garcia-Ribas, Dominique Tersago, · 2024
Read Efficacy and Safety of the Anti-IL1RAP Antibody Nadunolimab (CAN04) in Combination with Gemcitabine and Nab-Paclitaxel in Patients with Advanced/Metastatic Pancreatic Cancer by Eric Van Cutsem, Joelle Collignon, Rikke L. Eefsen, Sebastian Ochsenreither, Zanete Zvirbule, Audrius Ivanauskas, Dirk Arnold, Edita Baltruskeviciene, Per Pfeiffer, Jeffrey Yachnin, Susanne Magnusson, Camilla Rydberg Millrud, Annika Sanfridson, Nedjad Losic, Ignacio Garcia-Ribas, Dominique Tersago, (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11609625.txt.
Description
Eric Van Cutsem and a large team test a new antibody drug for pancreatic cancer in this two thousand twenty-four trial report. The drug, nadunolimab, blocks a protein that helps the IL1 signal drive tumor growth. That signal is tied to spread, drug resistance, and poor survival in this cancer. The antibody also marks cells for attack by the immune system. Patients had advanced cancer that could not be treated before.
They received the antibody every two weeks alongside two standard chemotherapy drugs. The main goal was safety, with tumor shrinkage as a second measure. Doses ranged across several levels to find a workable one. Advanced pancreatic cancer has few good options, so any safe gain matters. The paper reports on an early-phase trial, not a final verdict.
Catalog record
| CREATOR | Eric Van Cutsem, Joelle Collignon, Rikke L. Eefsen, Sebastian Ochsenreither, Zanete Zvirbule, Audrius Ivanauskas, Dirk Arnold, Edita Baltruskeviciene, Per Pfeiffer, Jeffrey Yachnin, Susanne Magnusson, Camilla Rydberg Millrud, Annika Sanfridson, Nedjad Losic, Ignacio Garcia-Ribas, Dominique Tersago, |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |