Early Hints of Metagenome Next‐Generation Sequencing and Copy Number Variations Analysis: An Occult Case of Leptomeningeal Metastasis With Rapid Cognitive Decline
Xueqin Chen, Haotao Zheng, Taoli Wang, Ziyang Feng, Jia Wang, Yangsicheng Liu, Wenxin Qin, Fanxin Kong, Xiude Qin · 2024
Read Early Hints of Metagenome Next‐Generation Sequencing and Copy Number Variations Analysis: An Occult Case of Leptomeningeal Metastasis With Rapid Cognitive Decline by Xueqin Chen, Haotao Zheng, Taoli Wang, Ziyang Feng, Jia Wang, Yangsicheng Liu, Wenxin Qin, Fanxin Kong, Xiude Qin (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11609582.txt.
Description
Xueqin Chen and co-authors caught hidden cancer spread to the meninges in two thousand twenty-four. A lung cancer patient declined in thinking speed rapidly. Scans showed only swollen brain tissue, nothing specific. Standard spinal fluid cell checks came back negative. Spread to the brain's lining was still suspected. Two newer fluid tests were brought in.
Gene sequencing of the fluid hinted at cancer DNA. Copy number patterns strengthened that hint early. Later cell checks confirmed the lining spread. The case shows sequencing can outrun cytology. Early proof matters because treatment windows are short. Clinicians facing vague decline gain a diagnostic route. The report urges wider use of fluid genomics.
Catalog record
| CREATOR | Xueqin Chen, Haotao Zheng, Taoli Wang, Ziyang Feng, Jia Wang, Yangsicheng Liu, Wenxin Qin, Fanxin Kong, Xiude Qin |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 16 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |