Protective effect of mesenchymal stromal cells in diabetic nephropathy: the In vitro and In vivo role of the M-Sec-tunneling nanotubes
Federica Barutta, Beatrice Corbetta, Stefania Bellini, Roberto Gambino, Stefania Bruno, Shunsuke Kimura, Koji Hase, Hiroshi Ohno, Gabriella Gruden · 2024
Read Protective effect of mesenchymal stromal cells in diabetic nephropathy: the In vitro and In vivo role of the M-Sec-tunneling nanotubes by Federica Barutta, Beatrice Corbetta, Stefania Bellini, Roberto Gambino, Stefania Bruno, Shunsuke Kimura, Koji Hase, Hiroshi Ohno, Gabriella Gruden (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11609313.txt.
Description
Federica Barutta and co-authors tested stem cell rescue in diabetic kidneys in two thousand twenty-four. Diabetes damages podocytes, the cells that filter blood. Their power units fail early in that damage. Neighboring cells can share power units through tiny tubes. Mesenchymal stromal cells are eager donors of such units. Whether they tube-connect to podocytes was unknown.
The team grew podocytes stressed by diabetes-like insults. Stromal cells were then cultured alongside them. Tube formation and power unit transfer were tracked. Injury markers showed whether rescue actually occurred. Diabetic donor cells were compared with healthy ones. Mice with kidney disease received the cells as treatment. Tagged power units revealed transfer inside living tissue.
Catalog record
| CREATOR | Federica Barutta, Beatrice Corbetta, Stefania Bellini, Roberto Gambino, Stefania Bruno, Shunsuke Kimura, Koji Hase, Hiroshi Ohno, Gabriella Gruden |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 64 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |