Ultrasound Control of Genomic Regulatory Toolboxes for Cancer Immunotherapy
Yiqian Wu, Ziliang Huang, Yahan Liu, Peixiang He, Yuxuan Wang, Liyanran Yan, Xinhui Wang, Shanzi Gao, Xintao Zhou, Chi Woo Yoon, Kun Sun, Yinglin Situ, Phuong Ho, Yushun Zeng, Zhou Yuan, Linshan Zhu, Qifa Zhou, Yunde Zhao, Thomas Liu, Gabriel A. Kwong, Shu Chien, Longwei Liu, Yingxiao Wang · 2024
Read Ultrasound Control of Genomic Regulatory Toolboxes for Cancer Immunotherapy by Yiqian Wu, Ziliang Huang, Yahan Liu, Peixiang He, Yuxuan Wang, Liyanran Yan, Xinhui Wang, Shanzi Gao, Xintao Zhou, Chi Woo Yoon, Kun Sun, Yinglin Situ, Phuong Ho, Yushun Zeng, Zhou Yuan, Linshan Zhu, Qifa Zhou, Yunde Zhao, Thomas Liu, Gabriel A. Kwong, Shu Chien, Longwei Liu, Yingxiao Wang (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11609292.txt.
Description
Yiqian Wu and co-authors report a bioengineering study, printed in 2024, putting gene editing tools under the control of ultrasound. Focused ultrasound heats a chosen spot deep in tissue, and the team wired that heat switch to CRISPR systems that can cut genes, switch them on, or rewrite their chemical marks. The tools worked across all three modes in cells.
In tumors, ultrasound triggered cutting of chromosome ends, priming the cancer for immune attack. Delivered by viruses into mice, the system woke killer T cells inside a patch of tumor, training them to hunt a universal cancer target nearby. The authors present sound controlled editing as a precise, noninvasive lever for cancer immunotherapy.
Catalog record
| CREATOR | Yiqian Wu, Ziliang Huang, Yahan Liu, Peixiang He, Yuxuan Wang, Liyanran Yan, Xinhui Wang, Shanzi Gao, Xintao Zhou, Chi Woo Yoon, Kun Sun, Yinglin Situ, Phuong Ho, Yushun Zeng, Zhou Yuan, Linshan Zhu, Qifa Zhou, Yunde Zhao, Thomas Liu, Gabriel A. Kwong, Shu Chien, Longwei Liu, Yingxiao Wang |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 72 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |