Curcumin mitigates polycystic ovary syndrome in mice by suppressing TLR4/MyD88/NF-κB signaling pathway activation and reducing intestinal mucosal permeability
Qin Yang, Qin Wan, Zhen Wang · 2024
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Description
Qin Yang, Qin Wan, and Zhen Wang test whether curcumin, a spice compound, eases a hormone disorder in mice. Their 2024 study deals with polycystic ovary syndrome, a condition tied to long term swelling. Curcumin is known to help the gut barrier and cut low grade swelling. Mice were split into four groups of fifteen: control, control plus curcumin, model, and model plus curcumin.
A hormone injection induced a like state in the model groups. After forty five days of curcumin, treated model mice weighed less. Male hormone and one pituitary hormone fell, while a female hormone and insulin sensitivity rose. Ovary and colon tissue looked healthier. Proteins that seal the gut wall rose. A signaling path that drives swelling was suppressed, the authors report.
Catalog record
| CREATOR | Qin Yang, Qin Wan, Zhen Wang |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 29 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |