Modeling metabolic-associated steatohepatitis with human pluripotent stem cell-derived liver organoids
Xiaoshan Wu, Dacheng Jiang, Yuchen Wang, Xin Li, Chenyu Liu, Yanhao Chen, Wei Sun, Ruikun He, Yi Yang, Xiaosong Gu, Chunping Jiang, Qiurong Ding · 2024
Read Modeling metabolic-associated steatohepatitis with human pluripotent stem cell-derived liver organoids by Xiaoshan Wu, Dacheng Jiang, Yuchen Wang, Xin Li, Chenyu Liu, Yanhao Chen, Wei Sun, Ruikun He, Yi Yang, Xiaosong Gu, Chunping Jiang, Qiurong Ding (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11608672.txt.
Description
Xiaoshan Wu and co-authors grow liver organoids that mimic a fatty liver disease in a 2024 study. The disease, metabolic-associated steatohepatitis, inflames a fat-laden liver and affects a few percent of people worldwide. Mini-livers grown from human stem cells had been used to model it before, but the models lacked deep molecular checks and needed refinement.
The team treated their organoids with oleic acid, a fat, plus a growth signal that drives scarring, to push them toward the disease state. They then read gene activity in bulk and cell by cell. Stains and tests tracked fat buildup, cell stress, damage, and collagen, the scar protein. The richer portrait makes the organoid a better stand-in for testing drugs against a disease that still has few treatments.
Catalog record
| CREATOR | Xiaoshan Wu, Dacheng Jiang, Yuchen Wang, Xin Li, Chenyu Liu, Yanhao Chen, Wei Sun, Ruikun He, Yi Yang, Xiaosong Gu, Chunping Jiang, Qiurong Ding |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |