A Novel Rat Model to Simulate Positive Margins in the Wound Bed of a Resected Sarcoma
Gurtej Singh, Omer Kaymakcalan, Thomas R. Hays, Adam Abbas, Sruthi Sridevan, Jasleen Kaur, Sourish Rathi, Jocellie Marquez, Soosan Ghazizadeh, Felix Tavernier, Brendan F. Boyce, Sami U. Khan, Fazel A. Khan, Duc T. Bui, Alexander B. Dagum · 2024
Read A Novel Rat Model to Simulate Positive Margins in the Wound Bed of a Resected Sarcoma by Gurtej Singh, Omer Kaymakcalan, Thomas R. Hays, Adam Abbas, Sruthi Sridevan, Jasleen Kaur, Sourish Rathi, Jocellie Marquez, Soosan Ghazizadeh, Felix Tavernier, Brendan F. Boyce, Sami U. Khan, Fazel A. Khan, Duc T. Bui, Alexander B. Dagum (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11608645.txt.
Description
Gurtej Singh and co-authors create a rat model of leftover tumor after sarcoma surgery in this 2024 paper. Positive margins, where tumor cells remain in the wound, drive local recurrence. No standard model reproduced that microscopic burden. Their trick seeds cancer cells directly into a fresh surgical wound.
Four cell doses were spread on square wounds in nude rats. Wound covers protected the beds for nine days before analysis. High doses grew gross tumors reaching deep through the skin layers. Low doses left only microscopic tumor masses while wounds healed better. Inflammation patterns differed by dose as well. The low dose setup now lets researchers test margin treatments realistically.
Catalog record
| CREATOR | Gurtej Singh, Omer Kaymakcalan, Thomas R. Hays, Adam Abbas, Sruthi Sridevan, Jasleen Kaur, Sourish Rathi, Jocellie Marquez, Soosan Ghazizadeh, Felix Tavernier, Brendan F. Boyce, Sami U. Khan, Fazel A. Khan, Duc T. Bui, Alexander B. Dagum |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 26 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |