Advanced siRNA delivery in combating hepatitis B virus: mechanistic insights and recent updates
Linh Nguyen, Tiep Tien Nguyen, Ju-Yeon Kim, Jee-Heon Jeong · 2024
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Description
Hepatitis B still kills many each year, and current drugs slow the virus without clearing its surface flags. Linh Nguyen and co-authors review a gene-silencing therapy for the virus in a 2024 paper. Short RNA strands can mute the virus's genes, but bare strands break down fast and cannot cross cell walls.
The review traces carriers built to shield those strands and ferry them to liver cells. It covers the therapy's promise and the steps it has passed so far. Several products have reached human trials, the authors note. They close with open hurdles and where the field may go next. Safe delivery is the make-or-break step for this class of drugs.
Catalog record
| CREATOR | Linh Nguyen, Tiep Tien Nguyen, Ju-Yeon Kim, Jee-Heon Jeong |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |