Costunolide and dehydrocostus lactone alleviate ulcerative colitis via regulating TLR4, NF-κB and PI3K expression
Songting Liang, Chu Chen, Ruoshi Li, Guihua Jiang, Leilei Du · 2024
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Description
Songting Liang and four co-authors published a 2024 study of two plant compounds against ulcerative colitis, a chronic gut inflammation. Costunolide and dehydrocostus lactone come from costus root, a traditional remedy. The team first used network pharmacology to predict shared targets of the compounds and the disease, finding 39, then singled out key proteins by network analysis. Docking simulations showed both compounds can bind those targets.
Animal tests confirmed the predictions. Colitis mice lost weight and colon length, with three inflammation proteins turned up in colon tissue. Both compounds eased the damage and turned those same proteins down. The authors say the pair protects the colon by damping the TLR4, NF-kappa-B, and PI3K signals. The work pairs computer prediction with bench proof.
Catalog record
| CREATOR | Songting Liang, Chu Chen, Ruoshi Li, Guihua Jiang, Leilei Du |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |