Multi-protomics analysis identified host cellular pathways perturbed by tick-borne encephalitis virus infection
Liyan Sui, Wenfang Wang, Xuerui Guo, Yinghua Zhao, Tian Tian, Jinlong Zhang, Heming Wang, Yueshan Xu, Hongmiao Chi, Hanxi Xie, Wenbo Xu, Nan Liu, Li Zhao, Guangqi Song, Zedong Wang, Kaiyu Zhang, Lihe Che, Yicheng Zhao, Guoqing Wang, Quan Liu · 2024
Read Multi-protomics analysis identified host cellular pathways perturbed by tick-borne encephalitis virus infection by Liyan Sui, Wenfang Wang, Xuerui Guo, Yinghua Zhao, Tian Tian, Jinlong Zhang, Heming Wang, Yueshan Xu, Hongmiao Chi, Hanxi Xie, Wenbo Xu, Nan Liu, Li Zhao, Guangqi Song, Zedong Wang, Kaiyu Zhang, Lihe Che, Yicheng Zhao, Guoqing Wang, Quan Liu (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11608235.txt.
Description
Liyan Sui and co-authors map how a tick-borne virus reshapes host cells in 2024. The virus can cause severe brain illness in Europe and Asia. No strong drugs exist for it or for some kin viruses, so its inner workings matter.
The team measured three layers of cell proteins at once after infection. The virus hit the early immune response, ribosome building, self-eating of cell parts, and DNA repair. Two virus proteins were traced to specific harms in repair and cleanup. Drugs that block repair paths or key enzymes fought the virus well in tests, marking them as leads.
Catalog record
| CREATOR | Liyan Sui, Wenfang Wang, Xuerui Guo, Yinghua Zhao, Tian Tian, Jinlong Zhang, Heming Wang, Yueshan Xu, Hongmiao Chi, Hanxi Xie, Wenbo Xu, Nan Liu, Li Zhao, Guangqi Song, Zedong Wang, Kaiyu Zhang, Lihe Che, Yicheng Zhao, Guoqing Wang, Quan Liu |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 82 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |