The effects of plasma from patients with active thyroid-associated orbitopathy on the survival and inflammation of melanoma-associated fibroblasts
Huifang Chen, Shiyuan Chen, Zhenfeng Liu · 2024
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Description
Huifang Chen, Shiyuan Chen, and Zhenfeng Liu tested how blood plasma from eye disease patients affects support cells from melanoma in a 2024 study. The eye condition, thyroid-associated orbitopathy, involves active inflammation around the eye in Graves' disease. Its plasma was already known to inflame fibroblasts, the support cells in tissue.
The team took fibroblasts grown from melanoma tumors and bathed them in plasma from patients or healthy controls. They then measured how well the cells survived and how much inflammation they showed. The setup probes whether factors in patient blood can stir tumor-support cells, a link between autoimmunity and cancer settings. The work is early cell science, meant to flag mechanisms for deeper study.
Catalog record
| CREATOR | Huifang Chen, Shiyuan Chen, Zhenfeng Liu |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 27 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |