Age-related uterine changes and its association with poor reproductive outcomes: a systematic review and meta-analysis
Diana Marti-Garcia, Asunta Martinez-Martinez, Francisco Jose Sanz, Almudena Devesa-Peiro, Patricia Sebastian-Leon, Nataly del Aguila, Antonio Pellicer, Patricia Diaz-Gimeno · 2024
Read Age-related uterine changes and its association with poor reproductive outcomes: a systematic review and meta-analysis by Diana Marti-Garcia, Asunta Martinez-Martinez, Francisco Jose Sanz, Almudena Devesa-Peiro, Patricia Sebastian-Leon, Nataly del Aguila, Antonio Pellicer, Patricia Diaz-Gimeno (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11607893.txt.
Description
Diana Marti-Garcia and co-authors present a 2024 review on how aging changes the womb and fertility. Fertility drops steeply after the mid-thirties, and most blame falls on the ovaries. The lining of the womb must also be fit for pregnancy, yet its aging is underrated. The team gathered 142 studies, with 59 feeding pooled math on donated-egg transfers.
Age shrinks the uterus and thins its lining. Blood supply fades as vessels narrow and key arteries are lost. Tissue structure, cell mix, and hormone response all shift with age. Core tasks such as grip, growth, and readiness for an embryo falter. Women past 35 to 40 had thinner linings by about half a millimeter. Outcomes after transfer also worsened with age.
Catalog record
| CREATOR | Diana Marti-Garcia, Asunta Martinez-Martinez, Francisco Jose Sanz, Almudena Devesa-Peiro, Patricia Sebastian-Leon, Nataly del Aguila, Antonio Pellicer, Patricia Diaz-Gimeno |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 75 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |