Transmission cluster of cefiderocol-non-susceptible carbapenem-resistant Acinetobacter baumannii in cefiderocol-naïve individuals
Claudia Alteri, Antonio Teri, Maria Francesca Liporace, Antonio Muscatello, Leonardo Terranova, Margherita Carnevale Schianca, Federica Salari, Beatrice Silvia Orena, Flaminia Gentiloni Silverj, Mara Bernazzani, Simona Biscarini, Giulia Renisi, Lisa Cariani, Caterina Matinato, Ciro Canetta, Alessand · 2024
Read Transmission cluster of cefiderocol-non-susceptible carbapenem-resistant Acinetobacter baumannii in cefiderocol-naïve individuals by Claudia Alteri, Antonio Teri, Maria Francesca Liporace, Antonio Muscatello, Leonardo Terranova, Margherita Carnevale Schianca, Federica Salari, Beatrice Silvia Orena, Flaminia Gentiloni Silverj, Mara Bernazzani, Simona Biscarini, Giulia Renisi, Lisa Cariani, Caterina Matinato, Ciro Canetta, Alessand (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11607823.txt.
Description
Claudia Alteri and co-workers tell of a ward germ that beat a last chance drug in patients who had not had that drug at all. Cefiderocol is kept for Acinetobacter baumannii strains that beat carbapenem drugs. Drug strength loss most often grows while on the drug. In one Milan ward from March to July 2024, staff saw 33 such cases. Gene scans ran on 29 samples.
Most samples sat in one line, but four sat in a next line. Just those four could not be curbed by cefiderocol. They shared an early stop and a lost chunk in the PirA protein. Since the patients had not had the drug, the strength must have come in by spread, not grown on site. The 2024 report warns ward teams to watch for drug strength brought in from the world past the ward.
Catalog record
| CREATOR | Claudia Alteri, Antonio Teri, Maria Francesca Liporace, Antonio Muscatello, Leonardo Terranova, Margherita Carnevale Schianca, Federica Salari, Beatrice Silvia Orena, Flaminia Gentiloni Silverj, Mara Bernazzani, Simona Biscarini, Giulia Renisi, Lisa Cariani, Caterina Matinato, Ciro Canetta, Alessand |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 18 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |