Protective role of TRPV1+ nociceptive neurons communication to macrophages against T. cruzi infection in mice
Sergio M. Borghi, Aparecida D. Malvezi, Maria Isabel Lovo-Martins, Victor Fattori, Tiago H. Zaninelli, Mariana M. Bertozzi, Camila R. Ferraz, Thiago M. Cunha, Rubia Casagrande, Marli C. Martins-Pinge, Phileno Pinge-Filho, Waldiceu A. Verri · 2024
Read Protective role of TRPV1+ nociceptive neurons communication to macrophages against T. cruzi infection in mice by Sergio M. Borghi, Aparecida D. Malvezi, Maria Isabel Lovo-Martins, Victor Fattori, Tiago H. Zaninelli, Mariana M. Bertozzi, Camila R. Ferraz, Thiago M. Cunha, Rubia Casagrande, Marli C. Martins-Pinge, Phileno Pinge-Filho, Waldiceu A. Verri (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11607651.txt.
Description
Sergio Borghi and co-authors show that pain-sensing neurons help mice fight off the parasite that causes Chagas disease. The parasite, Trypanosoma cruzi, invades the nervous system early and switches pain neurons on. Their 2024 paper asks what the neurons carrying the TRPV1 sensor do during infection, beyond carrying pain signals to immune cells called macrophages.
Parasites appeared in the spinal cord and its nerve roots early in infection, and injecting parasite material into the cord caused pain. Silencing TRPV1 eased that pain, but removing the neurons entirely let parasites multiply in the blood. Mice lacking TRPV1 died at a rate of half in a normally survivable infection, with worse organ damage and skewed immune signals. Blocking the sensor in patients may therefore carry a hidden cost. The study recasts pain neurons as active defenders, not just alarms.
Catalog record
| CREATOR | Sergio M. Borghi, Aparecida D. Malvezi, Maria Isabel Lovo-Martins, Victor Fattori, Tiago H. Zaninelli, Mariana M. Bertozzi, Camila R. Ferraz, Thiago M. Cunha, Rubia Casagrande, Marli C. Martins-Pinge, Phileno Pinge-Filho, Waldiceu A. Verri |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 28 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |