KANK1 promotes breast cancer development by compromising Scribble-mediated Hippo activation
Shiny Shengzhen Guo, Zhiying Liu, Guan M Wang, Zhiqi Sun, Kaikai Yu, James P Fawcett, Reinhard Buettner, Bo Gao, Reinhard Fässler · 2024
Read KANK1 promotes breast cancer development by compromising Scribble-mediated Hippo activation by Shiny Shengzhen Guo, Zhiying Liu, Guan M Wang, Zhiqi Sun, Kaikai Yu, James P Fawcett, Reinhard Buettner, Bo Gao, Reinhard Fässler (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11607453.txt.
Description
Shiny Shengzhen Guo and a team of co-authors studied a protein called KANK1 in breast cancer for a 2024 paper. Past lab work hinted the protein might slow cancer growth. Yet patient data tied high levels of it to poor outcomes in many cancers, a clash the team set out to resolve.
In mice, KANK1 helped breast tumor cells grow and survive once they left their base layer. There it blocked a helper protein, Scribble, from switching on the Hippo pathway, which acts as a brake on growth. With the brake off, a growth driver built up in the cell nucleus. The work casts KANK1 as a promoter of this cancer, not a brake.
Catalog record
| CREATOR | Shiny Shengzhen Guo, Zhiying Liu, Guan M Wang, Zhiqi Sun, Kaikai Yu, James P Fawcett, Reinhard Buettner, Bo Gao, Reinhard Fässler |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 70 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |