Approaches to investigate tissue-resident innate lymphocytes metabolism at the single-cell level
Carrie Corkish, Cristhiane Favero Aguiar, David K Finlay · 2024
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Description
Carrie Corkish and co-authors review how to study metabolism in tissue-resident innate lymphocytes one cell at a time in a 2024 paper. These immune cells guard organs in health and disease, but they are rare and hard to harvest.
Most past work used lab-grown cells or bulk samples, both of which can distort the true metabolic state. The review sums up what is known about fuel use in innate lymphoid cells, natural killer cells, and their kin. It flags traps in current methods and makes the case for single-cell metabolic assays run straight on fresh tissue. Such tools could reveal how resident cells power defense without culture artifacts.
Catalog record
| CREATOR | Carrie Corkish, Cristhiane Favero Aguiar, David K Finlay |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |