DNA breakpoints and free DNA fragments as potential predictors of infertility
Yue Zhou, Juan Wang, Fan Zhang, Liguo Pei, Yue Chang, Bei Yan, Hongyan Wang · 2024
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Description
Yue Zhou and six co-authors test whether broken sperm DNA can predict male infertility, in a 2024 study. The focus is varicocele, swollen veins in the scrotum that can harm sperm. Samples came from forty-two patients with the condition and twenty-two healthy men. Standard counts and vitality were assessed first. Three DNA harm markers were then measured with a new probe method: a fragmentation index, the mean number of breaks, and the amount of free DNA fragments in seminal fluid.
All three markers ran higher in the infertile patients. Combining the break count with the free fragment amount predicted fertility better than either alone. It also beat the standard index. The authors caution that larger, stricter studies must confirm the pair before clinics adopt it.
Catalog record
| CREATOR | Yue Zhou, Juan Wang, Fan Zhang, Liguo Pei, Yue Chang, Bei Yan, Hongyan Wang |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 26 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |