Triptolide induces apoptosis of glioma cells by inhibiting NF-κB activation during oxidative stress
Xinglan Li, Yubang Shan, Si Wang, Jia Wang, Xueyuan Heng · 2024
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Description
Xinglan Li and four co-authors test a plant compound against glioma, a deadly brain tumor, in a 2024 paper. Standard rays and drugs do little to lift survival, so new options are sought. The compound, triptolide, comes from a vine used in Chinese medicine and is known to calm swelling and slow cell growth. The team asks how it kills glioma cells.
Computer mapping of drug and disease targets pointed to a master switch for swelling, called NF-kB. Lab tests then showed the compound cut cell survival and movement, and pushed cells toward self-destruction. It did so, the team finds, by blocking that switch while raising harsh oxygen by-products inside the cells. Two cell fate markers shifted in line with that story.
Catalog record
| CREATOR | Xinglan Li, Yubang Shan, Si Wang, Jia Wang, Xueyuan Heng |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |