Multiple myeloma long-term survivors exhibit sustained immune alterations decades after first-line therapy
Raphael Lutz, Florian Grünschläger, Malte Simon, Mohamed H. S. Awwad, Marcus Bauer, Schayan Yousefian, Niklas Beumer, Lea Jopp-Saile, Anastasia Sedlmeier, Llorenç Solé-Boldo, Bogdan Avanesyan, Dominik Vonficht, Patrick Stelmach, Georg Steinbuss, Tobias Boch, Simon Steiger, Marc-Andrea Baertsch, Nina · 2024
Read Multiple myeloma long-term survivors exhibit sustained immune alterations decades after first-line therapy by Raphael Lutz, Florian Grünschläger, Malte Simon, Mohamed H. S. Awwad, Marcus Bauer, Schayan Yousefian, Niklas Beumer, Lea Jopp-Saile, Anastasia Sedlmeier, Llorenç Solé-Boldo, Bogdan Avanesyan, Dominik Vonficht, Patrick Stelmach, Georg Steinbuss, Tobias Boch, Simon Steiger, Marc-Andrea Baertsch, Nina (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11607340.txt.
Description
Lutz and co-authors study the immune systems of people who survive multiple myeloma for many years, in a research paper from 2024. How cancer and its treatment shape immunity long after cure was poorly known. The team profiled bone marrow from survivors up to 17 years after a single line of therapy.
Single-cell and molecular tests showed deep, lasting changes in the marrow immune setting, tied to weaker immunity. The changes often linked to an inflammatory circuit fed by leftover or returning myeloma cells. Even with no trace of disease for decades, the immune shifts stayed. The authors call that pattern immunological scarring from the first bout with cancer and its care. The work maps which changes fade and which do not.
Catalog record
| CREATOR | Raphael Lutz, Florian Grünschläger, Malte Simon, Mohamed H. S. Awwad, Marcus Bauer, Schayan Yousefian, Niklas Beumer, Lea Jopp-Saile, Anastasia Sedlmeier, Llorenç Solé-Boldo, Bogdan Avanesyan, Dominik Vonficht, Patrick Stelmach, Georg Steinbuss, Tobias Boch, Simon Steiger, Marc-Andrea Baertsch, Nina |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 98 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |