Predictors and Outcomes of Inappropriate Dosing of Direct Oral Anticoagulants in Patients Receiving Transcatheter Aortic Valve Implantation
Danial Amoey, Mohamed Samy, Karim Elbasha, Ahmad Alali, Martin Landt, Arief Kurniadi, Holger Nef, Ralph Tölg, Gert Richardt, Nader Mankerious · 2024
Read Predictors and Outcomes of Inappropriate Dosing of Direct Oral Anticoagulants in Patients Receiving Transcatheter Aortic Valve Implantation by Danial Amoey, Mohamed Samy, Karim Elbasha, Ahmad Alali, Martin Landt, Arief Kurniadi, Holger Nef, Ralph Tölg, Gert Richardt, Nader Mankerious (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11607234.txt.
Description
Danial Amoey and nine co-authors study wrong dosing of blood thinners after a heart valve procedure, in this 2024 paper. Patients who get a replacement aortic valve through a catheter often take direct oral anticoagulants, whose dose must match age, kidney function, and weight. How often doses go wrong in this group, and whether it matters, was unclear.
The single-center study covered 432 such patients treated from 2015 to 2022. About one in five, 20.6 percent, had an off-label dose. Wrong dosing clustered in women and in patients with weaker kidneys, and it was rarer with one drug, rivaroxaban. After one year, the pooled rate of death, major bleeding, stroke, and heart attack was about the same for right and wrong doses. Age and anemia, not dose, predicted bad outcomes. The authors still urge care with dosing rules.
Catalog record
| CREATOR | Danial Amoey, Mohamed Samy, Karim Elbasha, Ahmad Alali, Martin Landt, Arief Kurniadi, Holger Nef, Ralph Tölg, Gert Richardt, Nader Mankerious |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |