Hepatocyte‐Specific HuR Protects Against Acetaminophen‐Induced Liver Injury in Mice
Linlin Lu, Jicui Chen, Hui Jiang, Ni Li, Xiaojie Li, Yinghao Liu, Chen Zong · 2024
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Description
A peer-reviewed research article from Europe PMC (2024). Acetaminophen (APAP) overdose is a major cause of drug‐induced liver injury (DILI) in many countries. Hepatocyte proliferation, autophagy and antioxidant capacity are crucial to the prognosis of APAP‐induced liver injury, but the underlying mechanisms are not fully understood. Here, we found that human antigen R (HuR) protein expression was markedly increased in the model of APAP‐induced liver injury, and conditional hepatocyte‐specific HuR knockout aggravated APAP‐induced liver injury in mice.
Catalog record
| CREATOR | Linlin Lu, Jicui Chen, Hui Jiang, Ni Li, Xiaojie Li, Yinghao Liu, Chen Zong |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |