Pharmacogenetic‐guided dosing for fluoropyrimidine (DPYD) and irinotecan (UGT1A1*28) chemotherapies for patients with cancer (PACIFIC‐PGx): A multicenter clinical trial
Sarah Glewis, Senthil Lingaratnam, Benjamin Lee, Ian Campbell, Maarten IJzerman, Mussab Fagery, Sam Harris, Chloe Georgiou, Craig Underhill, Mark Warren, Robert Campbell, Madawa Jayawardana, S Sandun M Silva, Jennifer H Martin, Jeanne Tie, Marliese Alexander, Michael Michael · 2024
Read Pharmacogenetic‐guided dosing for fluoropyrimidine (DPYD) and irinotecan (UGT1A1*28) chemotherapies for patients with cancer (PACIFIC‐PGx): A multicenter clinical trial by Sarah Glewis, Senthil Lingaratnam, Benjamin Lee, Ian Campbell, Maarten IJzerman, Mussab Fagery, Sam Harris, Chloe Georgiou, Craig Underhill, Mark Warren, Robert Campbell, Madawa Jayawardana, S Sandun M Silva, Jennifer H Martin, Jeanne Tie, Marliese Alexander, Michael Michael (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11606843.txt.
Description
Sarah Glewis and co-authors run in 2024 a trial of gene-guided dosing for two common cancer drugs in Australia. Some patients carry gene forms that slow how they clear these drugs, which raises the risk of severe side effects. Testing first lets doctors cut the dose for those patients.
Four hospitals enrolled most patients they screened, and gene results came back in about a week, before the first dose in near all cases. About four percent needed a halved dose for one drug. Those patients suffered far fewer severe side effects than past patients dosed without gene checks. The trial shows gene-guided dosing can work in routine care.
Catalog record
| CREATOR | Sarah Glewis, Senthil Lingaratnam, Benjamin Lee, Ian Campbell, Maarten IJzerman, Mussab Fagery, Sam Harris, Chloe Georgiou, Craig Underhill, Mark Warren, Robert Campbell, Madawa Jayawardana, S Sandun M Silva, Jennifer H Martin, Jeanne Tie, Marliese Alexander, Michael Michael |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |