Statin use is associated with higher white matter hyperintensity volumes and lower grey matter volumes
Mélissa Gentreau, Maud Miguet, Oreste Affatato, Gull Rukh, Helgi Birgir Schiöth · 2024
Read Statin use is associated with higher white matter hyperintensity volumes and lower grey matter volumes by Mélissa Gentreau, Maud Miguet, Oreste Affatato, Gull Rukh, Helgi Birgir Schiöth (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11606650.txt.
Description
Mélissa Gentreau and co-authors asked, in a 2024 study, whether people who take statins show different brain volumes years later. Statins are widely used to prevent heart disease, but their long-term links with the brain are poorly known and past findings conflict. The team used UK Biobank data on middle-aged and older adults with no brain or mental disorders.
The study compared 3,285 statin users with 36,229 non-users, with brain scans taken nine years after the first measures. Statin users showed lower grey matter volume and higher volumes of white matter damage spots, while total white matter did not differ. Some of the grey matter gap ran through lower cholesterol. The authors read the pattern as a sign of faster brain aging, while noting the study shows links, not causes.
Catalog record
| CREATOR | Mélissa Gentreau, Maud Miguet, Oreste Affatato, Gull Rukh, Helgi Birgir Schiöth |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |