Blood metabolomic profiling reveals new targets in the management of psychological symptoms associated with severe alcohol use disorder
Sophie Leclercq, Hany Ahmed, Camille Amadieu, Géraldine Petit, Ville Koistinen, Quentin Leyrolle, Marie Poncin, Peter Stärkel, Eloise Kok, Pekka J Karhunen, Philippe de Timary, Sophie Laye, Audrey M Neyrinck, Olli K Kärkkäinen, Kati Hanhineva, Nathalie Delzenne, Christoph Buettner, Sophie Leclercq, · 2024
Read Blood metabolomic profiling reveals new targets in the management of psychological symptoms associated with severe alcohol use disorder by Sophie Leclercq, Hany Ahmed, Camille Amadieu, Géraldine Petit, Ville Koistinen, Quentin Leyrolle, Marie Poncin, Peter Stärkel, Eloise Kok, Pekka J Karhunen, Philippe de Timary, Sophie Laye, Audrey M Neyrinck, Olli K Kärkkäinen, Kati Hanhineva, Nathalie Delzenne, Christoph Buettner, Sophie Leclercq, (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11606602.txt.
Description
Sophie Leclercq and co-authors profile blood chemistry in severe alcohol use disorder and after three weeks sober, in a 2024 study. Alcohol addiction remains hard to treat, partly because its biology is still sketchy. Blood carries thousands of small molecules reflecting diet, gut microbes, and body state — a rich place to hunt for clues and drug targets.
Ninety-six patients gave blood for untargeted chemical profiling. Patterns were tied to the psychological symptoms patients reported, and profiles before and after abstinence were compared to see what normalizes. Molecules that track mood or craving could become targets for medicines that support recovery. Chemistry that heals with sobriety also hints at what drinking breaks.
Catalog record
| CREATOR | Sophie Leclercq, Hany Ahmed, Camille Amadieu, Géraldine Petit, Ville Koistinen, Quentin Leyrolle, Marie Poncin, Peter Stärkel, Eloise Kok, Pekka J Karhunen, Philippe de Timary, Sophie Laye, Audrey M Neyrinck, Olli K Kärkkäinen, Kati Hanhineva, Nathalie Delzenne, Christoph Buettner, Sophie Leclercq, |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 105 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |