Mechanism and prospects of mitochondrial transplantation for spinal cord injury treatment
Qin Wang, Xin Wang, Zhizhong Shang, Long Zhao · 2024
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Description
A spinal cord injury starves surviving cells of energy, because the mitochondria that power them are damaged in the cascade that follows. Qin Wang, Xin Wang, Zhizhong Shang, and Long Zhao review a bold repair idea in this 2024 paper: transplant fresh mitochondria into the injured cord. Donor power plants, from the patient or another source, would refill the energy supply directly.
Early animal studies, the review finds, show fewer dying neurons and more regrowing fibers after transplant. The grafts seem to work through growth signals, calmer inflammation, less cell suicide, and better blood vessel growth. The authors map the mechanisms in detail and weigh what blocks the clinic: sourcing, delivery, survival of the grafts, and dosing. They frame the therapy as promising but young.
Catalog record
| CREATOR | Qin Wang, Xin Wang, Zhizhong Shang, Long Zhao |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |