Regioselective intermolecular carboamination of allylamines via nucleopalladation: empowering three-component synthesis of vicinal diamines†
Shib Nath Saha, Nityananda Ballav, Suman Ghosh, Mahiuddin Baidya · 2024
Read Regioselective intermolecular carboamination of allylamines via nucleopalladation: empowering three-component synthesis of vicinal diamines† by Shib Nath Saha, Nityananda Ballav, Suman Ghosh, Mahiuddin Baidya (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11606157.txt.
Description
Shib Nath Saha and three co-authors report a 2024 chemistry paper on building paired-nitrogen compounds called vicinal diamines. These structures appear in many useful molecules, but joining a carbon group and a nitrogen group across one double bond in a single step is hard to control. The team used a palladium catalyst to run the reaction between three partners at once.
A removable guide group on the starting material steered the attack to one end of the double bond every time. The guide also steadied a key palladium ring long enough for the carbon partner to join. The method worked across many starting materials, tolerated varied chemical groups, and scaled up well. The products could be reshaped into ring compounds or used as helpers in other reactions. The team even tailored known drug agents with it, showing practical reach.
Catalog record
| CREATOR | Shib Nath Saha, Nityananda Ballav, Suman Ghosh, Mahiuddin Baidya |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 19 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |