Estimating the causal effect of dexamethasone versus hydrocortisone on the neutrophil- lymphocyte ratio in critically ill COVID-19 patients from Tygerberg Hospital ICU using TMLE method
Ivan Nicholas Nkuhairwe, Tonya Marianne Esterhuizen, Lovemore Nyasha Sigwadhi, Jacques Lukenze Tamuzi, Rhoderick Machekano, Peter S Nyasulu · 2024
Read Estimating the causal effect of dexamethasone versus hydrocortisone on the neutrophil- lymphocyte ratio in critically ill COVID-19 patients from Tygerberg Hospital ICU using TMLE method by Ivan Nicholas Nkuhairwe, Tonya Marianne Esterhuizen, Lovemore Nyasha Sigwadhi, Jacques Lukenze Tamuzi, Rhoderick Machekano, Peter S Nyasulu (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11606140.txt.
Description
Ivan Nkuhairwe and co-authors compare two steroid drugs in gravely ill COVID-19 patients, in a 2024 study. The patients were treated in an intensive care unit in Cape Town, South Africa. The outcome was a blood ratio that signals how the disease is progressing. One drug was dexamethasone, and the other was hydrocortisone.
The team used a causal method built for data from routine care rather than a trial. Three flavors of that method were run, each with a different learning engine. Most patients had received dexamethasone, and the rest hydrocortisone. The estimated difference in the blood ratio on day five was not statistically firm. Each estimate's range crossed zero, so no winner can be claimed from this data.
Catalog record
| CREATOR | Ivan Nicholas Nkuhairwe, Tonya Marianne Esterhuizen, Lovemore Nyasha Sigwadhi, Jacques Lukenze Tamuzi, Rhoderick Machekano, Peter S Nyasulu |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |