Protocol for a multicentric, double-blind, randomised controlled trial of hyperbaric oxygen therapy (HBOT) versus sham for treating vaso-occlusive crisis (VOC) in sickle cell disease (SCD) in patients aged 8 years or older (HBOT-SCD study)
Jerome Stirnemann, Jacques Serratrice, Tamara Mann, Pierre Louge, Combescure Christophe, Kaveh Samii, Rodrigue Pignel, Thomas Agoritsas, Marc Ansari, Giovanna Cannas, Yves Chalandon, Laurent Cimasoni, Pierre Cougoul, Benoit Desgraz, Alain Gervaix, Olivier Grosgurin, Thierry Joffre, Claude Lae, Marie · 2024
Read Protocol for a multicentric, double-blind, randomised controlled trial of hyperbaric oxygen therapy (HBOT) versus sham for treating vaso-occlusive crisis (VOC) in sickle cell disease (SCD) in patients aged 8 years or older (HBOT-SCD study) by Jerome Stirnemann, Jacques Serratrice, Tamara Mann, Pierre Louge, Combescure Christophe, Kaveh Samii, Rodrigue Pignel, Thomas Agoritsas, Marc Ansari, Giovanna Cannas, Yves Chalandon, Laurent Cimasoni, Pierre Cougoul, Benoit Desgraz, Alain Gervaix, Olivier Grosgurin, Thierry Joffre, Claude Lae, Marie (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11605825.txt.
Description
Jerome Stirnemann and co-authors lay out a trial of pressurized oxygen for sickle cell pain crises in a 2024 protocol paper. Blocked vessels cause the searing bone and chest pain of these crises. Pressurized oxygen can raise tissue oxygen tenfold or more at once. A nine patient pilot hinted at safety and pain relief.
Patients aged eight and up at emergency units will join the blind trial. Three sessions over about two days pair real treatment against a sham setup. Pain change six hours after the first session anchors the main outcome. Cost and biology checks ride along. Usual crisis care continues for all, so the trial tests an add on, not a swap.
Catalog record
| CREATOR | Jerome Stirnemann, Jacques Serratrice, Tamara Mann, Pierre Louge, Combescure Christophe, Kaveh Samii, Rodrigue Pignel, Thomas Agoritsas, Marc Ansari, Giovanna Cannas, Yves Chalandon, Laurent Cimasoni, Pierre Cougoul, Benoit Desgraz, Alain Gervaix, Olivier Grosgurin, Thierry Joffre, Claude Lae, Marie |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |