10296- CBMS-8 CURCUMIN, AN INHIBITOR OF P300-HAT ACTIVITY, SUPPRESSED GLIOBLASTOMA CELL PROLIFERATION IN A STRUCTURE-ACTIVITY RELATIONSHIP STUDY
Kyoko Inai, Toshihide Hamabe-Horiike, Masaya Ono, Sonoka Iwashimizu, Ryo Ito, Syunsuke Nakanishi, Yuto Kawase, Ryuya Naruta, Yoichi Sunagawa, Yasufumi Katanasaka, Philip Hawke, Yoshiki Arakawa, Koji Hasegawa, Tatsuya Morimoto · 2024
Read 10296- CBMS-8 CURCUMIN, AN INHIBITOR OF P300-HAT ACTIVITY, SUPPRESSED GLIOBLASTOMA CELL PROLIFERATION IN A STRUCTURE-ACTIVITY RELATIONSHIP STUDY by Kyoko Inai, Toshihide Hamabe-Horiike, Masaya Ono, Sonoka Iwashimizu, Ryo Ito, Syunsuke Nakanishi, Yuto Kawase, Ryuya Naruta, Yoichi Sunagawa, Yasufumi Katanasaka, Philip Hawke, Yoshiki Arakawa, Koji Hasegawa, Tatsuya Morimoto (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11605602.txt.
Description
Kyoko Inai and co-authors test whether curcumin blocks brain tumor growth by disabling one enzyme activity. Their 2024 conference abstract concerns glioblastoma, the commonest malignant brain tumor, with a five-year survival near ten percent. The enzyme p300 helps switch genes on by adding acetyl groups, and its activity drives pancreatic cancer growth, but its role in this brain tumor was untested.
Curcumin inhibits that enzyme activity, while a close chemical cousin does not. Comparing the two compounds on a human glioblastoma cell line let the team isolate the enzyme's contribution to cell growth. A structure-activity design varied the molecule to find which parts carry the effect. The abstract reports the head-to-head comparison in tumor cells.
Catalog record
| CREATOR | Kyoko Inai, Toshihide Hamabe-Horiike, Masaya Ono, Sonoka Iwashimizu, Ryo Ito, Syunsuke Nakanishi, Yuto Kawase, Ryuya Naruta, Yoichi Sunagawa, Yasufumi Katanasaka, Philip Hawke, Yoshiki Arakawa, Koji Hasegawa, Tatsuya Morimoto |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |