IL-1 IDHWT GLIOBLASTOMA LONGITUDINAL MOLECULAR EVOLUTION
C G Lucas, N Al-Adli, J S Young, R Gupta, R A Morshed, J Wu, A Ravindranthan, A Shai, N A Oberheim Bush, J W Taylor, J de Groot, J E Villanueva-Meyer, M Pekmezci, A Perry, A W Bolen, P V Theodosopoulos, M K Aghi, E F Chang, S L Hervey-Jumper, D R Raleigh, A M Molinaro, J Costello, A A Diaz, J L Clar · 2024
Read IL-1 IDHWT GLIOBLASTOMA LONGITUDINAL MOLECULAR EVOLUTION by C G Lucas, N Al-Adli, J S Young, R Gupta, R A Morshed, J Wu, A Ravindranthan, A Shai, N A Oberheim Bush, J W Taylor, J de Groot, J E Villanueva-Meyer, M Pekmezci, A Perry, A W Bolen, P V Theodosopoulos, M K Aghi, E F Chang, S L Hervey-Jumper, D R Raleigh, A M Molinaro, J Costello, A A Diaz, J L Clar (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11605545.txt.
Description
How a harsh brain tumor changes as it grows back is traced in a 2024 talk abstract from a large team of brain tumor experts. The tumor is glioblastoma with a normal IDH gene form. The team paired first and repeat tumor samples from 106 patients. They checked tissue form, gene faults, and chemical marks on DNA in both sets.
Some gene faults came early and stayed in both samples. Most other faults sat in one sample only, gained late as cell lines split. Chemical marks shifted in mixed ways across cases. One change score built from many mark sites tracked how patients fared. Tumors that turned to a tougher form did worse.
Catalog record
| CREATOR | C G Lucas, N Al-Adli, J S Young, R Gupta, R A Morshed, J Wu, A Ravindranthan, A Shai, N A Oberheim Bush, J W Taylor, J de Groot, J E Villanueva-Meyer, M Pekmezci, A Perry, A W Bolen, P V Theodosopoulos, M K Aghi, E F Chang, S L Hervey-Jumper, D R Raleigh, A M Molinaro, J Costello, A A Diaz, J L Clar |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |