Choice of activation protocol impacts the yield and quality of CAR T cell product, particularly with older individuals
Palak H Mehta, Gemma S Trollope, Patrick Leung, Shivali Savita Chinni, Anna Iasinskaia, Aaron J Harrison, Hannah Hughes‐Parry, Misty R Jenkins, Michael H Kershaw, Anthony Jaworowski, Clare Y Slaney, Rachel M Koldej, David S Ritchie, Kylie M Quinn · 2024
Read Choice of activation protocol impacts the yield and quality of CAR T cell product, particularly with older individuals by Palak H Mehta, Gemma S Trollope, Patrick Leung, Shivali Savita Chinni, Anna Iasinskaia, Aaron J Harrison, Hannah Hughes‐Parry, Misty R Jenkins, Michael H Kershaw, Anthony Jaworowski, Clare Y Slaney, Rachel M Koldej, David S Ritchie, Kylie M Quinn (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11605362.txt.
Description
Palak Mehta and a large team of co-authors study how the way T cells are switched on affects a cell therapy for cancer. Their paper is from two thousand twenty-four. In this therapy, a patient's own T cells are reprogrammed in the lab to hunt cancer. Younger, less worn-out cells work better in patients, but older donors start with more worn-out cells.
The team made the therapy from blood of young and older healthy donors, using two switching methods. Older samples gave fewer, more worn-out cells under both methods. One method, using paired antibody complexes, made the age gap worse. A surface marker on the starting cells tracked how worn out the final product would be. The starting mix mattered even more than the marker.
Catalog record
| CREATOR | Palak H Mehta, Gemma S Trollope, Patrick Leung, Shivali Savita Chinni, Anna Iasinskaia, Aaron J Harrison, Hannah Hughes‐Parry, Misty R Jenkins, Michael H Kershaw, Anthony Jaworowski, Clare Y Slaney, Rachel M Koldej, David S Ritchie, Kylie M Quinn |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |