A blueprint for broadly effective bacteriophage-antibiotic cocktails against bacterial infections
Minyoung Kevin Kim, Qingquan Chen, Arne Echterhof, Nina Pennetzdorfer, Robert C McBride, Niaz Banaei, Elizabeth B Burgener, Carlos E Milla, Paul L Bollyky · 2024
Read A blueprint for broadly effective bacteriophage-antibiotic cocktails against bacterial infections by Minyoung Kevin Kim, Qingquan Chen, Arne Echterhof, Nina Pennetzdorfer, Robert C McBride, Niaz Banaei, Elizabeth B Burgener, Carlos E Milla, Paul L Bollyky (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11604943.txt.
Description
Minyoung Kevin Kim and colleagues present a two thousand twenty-four study designing broad phage and antibiotic cocktails for resistant infections. Virus-like phages kill bacteria, but each phage targets few strains. Personal therapy dominates because coverage is narrow.
The team grouped phages by which bacterial docking sites they use. Mixing groups with complementary targets blocked resistance from emerging. Certain antibiotic classes paired predictably with certain groups. Their three cocktails each covered nearly all tested Pseudomonas clinical strains, including biofilms. A wound infection animal model matched the lab success. Similar cocktails were built for Staphylococcus as well.
Catalog record
| CREATOR | Minyoung Kevin Kim, Qingquan Chen, Arne Echterhof, Nina Pennetzdorfer, Robert C McBride, Niaz Banaei, Elizabeth B Burgener, Carlos E Milla, Paul L Bollyky |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 73 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |