C/EBPβ-dependent autophagy inhibition hinders NK cell function in cancer
Federica Portale, Roberta Carriero, Marta Iovino, Paolo Kunderfranco, Marta Pandini, Giulia Marelli, Nicolò Morina, Massimo Lazzeri, Paolo Casale, Piergiuseppe Colombo, Gabriele De Simone, Chiara Camisaschi, Enrico Lugli, Gianluca Basso, Javier Cibella, Sergio Marchini, Matteo Bordi, Greta Meregalli · 2024
Read C/EBPβ-dependent autophagy inhibition hinders NK cell function in cancer by Federica Portale, Roberta Carriero, Marta Iovino, Paolo Kunderfranco, Marta Pandini, Giulia Marelli, Nicolò Morina, Massimo Lazzeri, Paolo Casale, Piergiuseppe Colombo, Gabriele De Simone, Chiara Camisaschi, Enrico Lugli, Gianluca Basso, Javier Cibella, Sergio Marchini, Matteo Bordi, Greta Meregalli (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11604937.txt.
Description
Federica Portale and co-authors ask, in a 2024 study, why natural killer cells lose their punch inside tumors. These immune cells can kill cancer, yet most solid tumors blunt them, and cell therapies often fail there. The team compared killer cells taken from human prostate tumors with those outside tumors. A gene scan pointed at autophagy, the cell's self-recycling process, as a key gap.
Tests in patients and in mouse models confirmed that tumors throw autophagy off track in these cells. Their energy stores sagged and their killing power fell. A protein called C/EBP beta, switched on by a tumor signal, drove the change. Blocking that signal chain, or switching autophagy back on by drugs or gene edits, restored the cells. Treated killer cells, including engineered CAR-NK cells, then controlled tumors better.
Catalog record
| CREATOR | Federica Portale, Roberta Carriero, Marta Iovino, Paolo Kunderfranco, Marta Pandini, Giulia Marelli, Nicolò Morina, Massimo Lazzeri, Paolo Casale, Piergiuseppe Colombo, Gabriele De Simone, Chiara Camisaschi, Enrico Lugli, Gianluca Basso, Javier Cibella, Sergio Marchini, Matteo Bordi, Greta Meregalli |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 97 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |