Dietary restriction interventions: lifespan benefits need resilience and are limited by immune compromise and genetics
Yulin Chen, Anjalika Malik, Karl Lenhard Rudolph · 2024
Read Dietary restriction interventions: lifespan benefits need resilience and are limited by immune compromise and genetics by Yulin Chen, Anjalika Malik, Karl Lenhard Rudolph (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11604914.txt.
Description
Yulin Chen, Anjalika Malik, and Karl Lenhard Rudolph comment on new evidence about who actually gains life from eating less, in this 2024 paper. A large mouse study in Nature compared two strengths of calorie cutting with two fasting schedules across genetically diverse animals. The headline result unsettles simple stories about dieting and aging.
Strong calorie cutting extended life far more than fasting did. Yet it also thinned immune cells and lean mass, which could cost disease resistance in people. Measures of slowed metabolism did not track who lived longest. Instead, resilience, the ability to hold body weight steady under stress, predicted longevity across every diet. The authors warn that genes and immune strength bound what dietary restriction can promise, and that personal resilience should guide its use.
Catalog record
| CREATOR | Yulin Chen, Anjalika Malik, Karl Lenhard Rudolph |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 9 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |