A DNA methylation signature identified in the buccal mucosa reflecting active tuberculosis is changing during tuberculosis treatment
Isabelle Öhrnberg, Lovisa Karlsson, Shumaila Sayyab, Jakob Paues, David Martínez-Enguita, Mika Gustafsson, Patricia Espinoza-Lopez, Melissa Méndez-Aranda, Ericka Meza, Cesar Ugarte-Gil, Nicholas Kiprotich, Lameck Diero, Ronald Tonui, Maria Lerm · 2024
Read A DNA methylation signature identified in the buccal mucosa reflecting active tuberculosis is changing during tuberculosis treatment by Isabelle Öhrnberg, Lovisa Karlsson, Shumaila Sayyab, Jakob Paues, David Martínez-Enguita, Mika Gustafsson, Patricia Espinoza-Lopez, Melissa Méndez-Aranda, Ericka Meza, Cesar Ugarte-Gil, Nicholas Kiprotich, Lameck Diero, Ronald Tonui, Maria Lerm (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11604703.txt.
Description
Ohrnberg leads a large team studying a DNA methylation signature for tuberculosis in cheek cells, in work from twenty twenty-four. Tuberculosis kills many people when untreated. Monitoring treatment now relies on sputum, which is hard to collect and analyze in many settings.
A methylation signature in buccal mucosa, the cheek lining, reflected active tuberculosis in their pilot work. The signature changed during treatment, tracking disease course. A cheek swab test would be painless and easy to ship. International samples from several countries tested the idea. Non invasive monitoring could transform follow up care where labs are scarce.
Catalog record
| CREATOR | Isabelle Öhrnberg, Lovisa Karlsson, Shumaila Sayyab, Jakob Paues, David Martínez-Enguita, Mika Gustafsson, Patricia Espinoza-Lopez, Melissa Méndez-Aranda, Ericka Meza, Cesar Ugarte-Gil, Nicholas Kiprotich, Lameck Diero, Ronald Tonui, Maria Lerm |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |