Ligand-enabled Ni-catalysed dicarbofunctionalisation of alkenes with diverse native functional groups
Dao-Ming Wang, Hui-Mei Shan, Li-Qin She, Yu-Qing He, Yichen Wu, Yong Tang, Li-Ping Xu, Peng Wang · 2024
Read Ligand-enabled Ni-catalysed dicarbofunctionalisation of alkenes with diverse native functional groups by Dao-Ming Wang, Hui-Mei Shan, Li-Qin She, Yu-Qing He, Yichen Wu, Yong Tang, Li-Ping Xu, Peng Wang (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11604661.txt.
Description
Dao-Ming Wang and co-authors report a new lab reaction in 2024 that joins two carbon groups to simple alkenes in one step. Past versions of the reaction needed strong helper groups added just to guide the metal, which cut the yield of the whole process. The team instead uses groups already present in the starting materials as guides.
A bulky helper compound lets a nickel catalyst do the joining under mild, balanced terms. The method works with many starting materials, among them amides and amines, and it scales up well. Lab tests and computer models both back the claim that the helper keeps key steps stable.
Catalog record
| CREATOR | Dao-Ming Wang, Hui-Mei Shan, Li-Qin She, Yu-Qing He, Yichen Wu, Yong Tang, Li-Ping Xu, Peng Wang |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |