Resolution of acute inflammation induced by monosodium urate crystals (MSU) through neutrophil extracellular trap-MSU aggregate-mediated negative signaling
Cheng-Hsun Lu, Chieh-Yu Shen, Ko-Jen Li, Cheng-Han Wu, Yu-Hsuan Chen, Yu-Min Kuo, Song-Chou Hsieh, Chia-Li Yu · 2024
Read Resolution of acute inflammation induced by monosodium urate crystals (MSU) through neutrophil extracellular trap-MSU aggregate-mediated negative signaling by Cheng-Hsun Lu, Chieh-Yu Shen, Ko-Jen Li, Cheng-Han Wu, Yu-Hsuan Chen, Yu-Min Kuo, Song-Chou Hsieh, Chia-Li Yu (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11604016.txt.
Description
Cheng-Hsun Lu and co-authors present a 2024 cell study of how gout flares calm down on their own. Urate crystals stir white blood cells into attack, yet most flares fade in a week or so. The cells cast DNA nets that trap crystals into clumps. The team asks whether those clumps help end the flare.
In a dish model, fresh cells plus fresh crystals made bigger clumps and a far lower inflammation score. Brake signals inside the cells rose, while go signals fell. Cell surface marks shifted to a calmer type. The authors say net clumps do more than trap crystals: they actively switch the response off.
Catalog record
| CREATOR | Cheng-Hsun Lu, Chieh-Yu Shen, Ko-Jen Li, Cheng-Han Wu, Yu-Hsuan Chen, Yu-Min Kuo, Song-Chou Hsieh, Chia-Li Yu |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |