Serum proteome profiling reveals HGFA as a candidate biomarker for pulmonary arterial hypertension
Meng Zhang, Haobo Li, Shuangshuang Ma, Xincheng Li, Linfeng Xi, Yishan Li, Zhu Zhang, Shuai Zhang, Qian Gao, Qiang Huang, Jun Wan, Wanmu Xie, Jifeng Li, Peiran Yang, Yunxia Zhang, Zhenguo Zhai · 2024
Read Serum proteome profiling reveals HGFA as a candidate biomarker for pulmonary arterial hypertension by Meng Zhang, Haobo Li, Shuangshuang Ma, Xincheng Li, Linfeng Xi, Yishan Li, Zhu Zhang, Shuai Zhang, Qian Gao, Qiang Huang, Jun Wan, Wanmu Xie, Jifeng Li, Peiran Yang, Yunxia Zhang, Zhenguo Zhai (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11603967.txt.
Description
Meng Zhang and co-authors searched blood samples for a marker of a serious lung vessel disease in a 2024 study. The disease, pulmonary arterial hypertension, strains the right side of the heart. A simple blood test that flags it early would help doctors act sooner.
The team compared blood proteins in patients and healthy controls, then checked the best leads with a second test. Three proteins stood out, and one, called HGFA, split patients from controls with the best accuracy. Low levels of that protein tracked with worse heart function. Gene-based checks and rat studies backed a real link to the disease, which makes the protein a strong lead for a future blood test.
Catalog record
| CREATOR | Meng Zhang, Haobo Li, Shuangshuang Ma, Xincheng Li, Linfeng Xi, Yishan Li, Zhu Zhang, Shuai Zhang, Qian Gao, Qiang Huang, Jun Wan, Wanmu Xie, Jifeng Li, Peiran Yang, Yunxia Zhang, Zhenguo Zhai |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |